Fig. 3

Proposed methodology for phenotyping Heart Failure with Preserved Ejection Fraction (HFpEF) through parameters derived from left heart myocardial mechanics. There are two mains distinct HFpEF phenotypes based on left ventricular strain: HFpEF with reduced longitudinal systolic function (HFpEF-rLS) and HFpEF with preserved longitudinal systolic function (HFpEF-pLS). Additionally, the integration of the left atrium strain reservoir (LASr) is suggested to introduce a comprehensive dimension addressing the impairments in both the left ventricle and left atrium. This proposed approach offers a nuanced perspective for refining HFpEF phenotyping and may contribute to targeted therapeutic insight