From: Effects of smoking cessation on endothelial function as assessed by flow-mediated total dilation
 | Change in %FMD |  |  |  |  |  |  | Change in %FMTD |  |  |  |  |  |  | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abstainers | Continued smokers | Difference | p-valuea | p-value for interaction | Abstainers | Continued smokers | Difference | p-valuea | p-value for interaction | |||||||
Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |||||||||||
Overall | 0.89 | (0.18 to 1.60) | 0.12 | (-0.87 to 1.11) | 0.77 | (-0.22 to 1.77) | 0.129 | Â | 0.49 | (-0.23 to 1.21) | -0.67 | (-1.69 to 0.34) | 1.17 | (0.16 to 2.18) | 0.024* | Â |
Sex |  |  |  |  |  |  |  | 0.189 |  |  |  |  |  |  |  | < 0.001** |
 Males | 0.80 | (0.07 to 1.52) | 0.37 | (-0.70 to 1.43) | 0.43 | (-0.69 to 1.55) | 0.452 |  | 0.24 | (-0.45 to 0.92) | 0.00 | (-1.00 to 1.01) | 0.24 | (-0.81 to 1.28) | 0.658 |  |
 Females | 1.75 | (0.63 to 2.87) | -0.38 | (-2.49 to 1.73) | 2.13 | (-0.14 to 4.40) | 0.066 |  | 2.37 | (1.33 to 3.42) | -3.03 | (-5.20 to -0.87) | 5.41 | (3.15 to 7.67) | < 0.001** |  |
Age, years | Â | Â | Â | Â | Â | Â | Â | 0.966 | Â | Â | Â | Â | Â | Â | Â | 0.065 |
 40 | 0.89 | (-0.23 to 2.00) | 0.08 | (-1.60 to 1.77) | 0.81 | (-1.11 to 2.73) | 0.411 |  | 1.01 | (-0.08 to 2.10) | -1.75 | (-3.52 to 0.02) | 2.76 | (0.79 to 4.72) | 0.006** |  |
 50 | 0.89 | (0.08 to 1.70) | 0.10 | (-1.03 to 1.24) | 0.79 | (-0.43 to 2.01) | 0.207 |  | 0.71 | (-0.09 to 1.50) | -1.14 | (-2.32 to 0.03) | 1.85 | (0.61 to 3.09) | 0.003** |  |
 60 | 0.89 | (0.17 to 1.61) | 0.13 | (-0.89 to 1.14) | 0.77 | (-0.26 to 1.79) | 0.145 |  | 0.41 | (-0.31 to 1.13) | -0.54 | (-1.56 to 0.48) | 0.95 | (-0.08 to 1.97) | 0.070 |  |
 70 | 0.89 | (-0.03 to 1.81) | 0.15 | (-1.30 to 1.59) | 0.74 | (-0.80 to 2.29) | 0.346 |  | 0.11 | (-0.81 to 1.03) | 0.06 | (-1.39 to 1.52) | 0.04 | (-1.51 to 1.60) | 0.955 |  |
BMI (baseline), kg/m2 | Â | Â | Â | Â | Â | Â | Â | 0.876 | Â | Â | Â | Â | Â | Â | Â | 0.284 |
 20.0 | 1.17 | (0.20 to 2.14) | 0.50 | (-0.84 to 1.83) | 0.68 | (-0.82 to 2.17) | 0.371 |  | 0.99 | (0.04 to 1.94) | -0.76 | (-2.07 to 0.54) | 1.75 | (0.29 to 3.22) | 0.019* |  |
 22.0 | 0.98 | (0.18 to 1.78) | 0.26 | (-0.84 to 1.36) | 0.72 | (-0.44 to 1.88) | 0.220 |  | 0.72 | (-0.07 to 1.50) | -0.74 | (-1.82 to 0.34) | 1.46 | (0.32 to 2.59) | 0.012* |  |
 24.0 | 0.79 | (0.06 to 1.53) | 0.03 | (-1.02 to 1.08) | 0.76 | (-0.28 to 1.80) | 0.148 |  | 0.44 | (-0.28 to 1.16) | -0.72 | (-1.75 to 0.31) | 1.16 | (0.14 to 2.18) | 0.026* |  |
 26.0 | 0.60 | (-0.19 to 1.39) | -0.20 | (-1.41 to 1.00) | 0.81 | (-0.39 to 2.01) | 0.185 |  | 0.16 | (-0.61 to 0.94) | -0.70 | (-1.88 to 0.49) | 0.86 | (-0.32 to 2.04) | 0.150 |  |
Cigarettes per day | Â | Â | Â | Â | Â | Â | Â | 0.206 | Â | Â | Â | Â | Â | Â | Â | 0.042* |
 10 | 1.45 | (0.46 to 2.45) | -0.25 | (-1.93 to 1.42) | 1.71 | (-0.12 to 3.53) | 0.067 |  | 0.93 | (-0.04 to 1.90) | -1.78 | (-3.41 to -0.15) | 2.71 | (0.93 to 4.49) | 0.003** |  |
 20 | 0.94 | (0.21 to 1.66) | -0.07 | (-1.15 to 1.00) | 1.01 | (-0.10 to 2.12) | 0.073 |  | 0.55 | (-0.16 to 1.25) | -1.07 | (-2.11 to -0.02) | 1.61 | (0.54 to 2.69) | 0.004** |  |
 30 | 0.42 | (-0.40 to 1.24) | 0.11 | (-1.01 to 1.22) | 0.32 | (-0.89 to 1.52) | 0.606 |  | 0.16 | (-0.64 to 0.96) | -0.36 | (-1.44 to 0.72) | 0.52 | (-0.66 to 1.70) | 0.383 |  |
 40 | -0.09 | (-1.29 to 1.10) | 0.29 | (-1.46 to 2.03) | -0.38 | (-2.39 to 1.63) | 0.709 |  | -0.22 | (-1.39 to 0.95) | 0.35 | (-1.35 to 2.05) | -0.57 | (-2.53 to 1.39) | 0.563 |  |
Hypertension | Â | Â | Â | Â | Â | Â | Â | 0.577 | Â | Â | Â | Â | Â | Â | Â | 0.577 |
 Yes | 0.79 | (-0.25 to 1.83) | 0.37 | (-0.94 to 1.67) | 0.42 | (-1.15 to 2.00) | 0.595 |  | 0.14 | (-0.89 to 1.17) | -0.71 | (-2.00 to 0.57) | 0.85 | (-0.70 to 2.41) | 0.280 |  |
 No | 0.93 | (0.17 to 1.69) | -0.08 | (-1.33 to 1.18) | 1.01 | (-0.35 to 2.36) | 0.144 |  | 0.54 | (-0.21 to 1.29) | -0.89 | (-2.12 to 0.35) | 1.42 | (0.09 to 2.76) | 0.037* |  |
Dbase (baseline), mm | Â | Â | Â | Â | Â | Â | Â | 0.552 | Â | Â | Â | Â | Â | Â | Â | 0.023* |
 3.00 | 0.80 | (-0.58 to 2.18) | -0.59 | (-2.87 to 1.69) | 1.39 | (-0.95 to 3.74) | 0.241 |  | 0.95 | (-0.38 to 2.28) | -2.58 | (-4.78 to -0.39) | 3.53 | (1.28 to 5.79) | 0.002** |  |
 4.00 | 0.88 | (0.12 to 1.64) | -0.01 | (-1.14 to 1.12) | 0.89 | (-0.23 to 2.02) | 0.119 |  | 0.56 | (-0.17 to 1.30) | -1.12 | (-2.20 to -0.03) | 1.68 | (0.59 to 2.76) | 0.003** |  |
 5.00 | 0.96 | (-0.08 to 1.99) | 0.56 | (-0.89 to 2.02) | 0.39 | (-1.21 to 1.99) | 0.627 |  | 0.17 | (-0.83 to 1.17) | 0.35 | (-1.06 to 1.76) | -0.18 | (-1.73 to 1.36) | 0.816 |  |